Publications
Huot JR*, Livingston PD*, Pin F, Thomas CR, Jamnick NA, Callaway CS, Bonetto A. Long-term musculoskeletal consequences of chemotherapy in pediatric mice. 2024 Function, in press
Balanta-Melo J*, Jones AJ*, Novinger LJ, Moore MG, Bonetto A. Masseter thickness is predictive of cancer cachexia in patients with head and neck cancer. 2024 Head & Neck, in press
Callaway CS, Mouchantat LM, Bitler BG, Bonetto A. Mechanisms of ovarian cancer-associated cachexia. 2023 Endocrinology, in press https://doi.org/10.1210/endocr/bqad176
Dolly A, Pötgens SA, Thibaut MM, Neyrinck AM, de Castro GS, Galbert C, Lefevre C, Wyart E, Gomes SP, Gonçalves DC, Lanthier N, Baldin P, Huot JR, Bonetto A, Seelaender M, Delzenne NM, Sokol H, Bindels LB. Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia. J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1569-1582. doi: 10.1002/jcsm.13246. Epub 2023 May 1. PubMed PMID: 37127348; PubMed Central PMCID: PMC10235873.
Huot JR, Baumfalk D, Resendiz A, Bonetto A, Smuder AJ, Penna F. Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting. Antioxid Redox Signal. 2023 Feb;38(4-6):352-370. doi: 10.1089/ars.2022.0149. Epub 2022 Dec 29. Review. PubMed PMID: 36310444; PubMed Central PMCID: PMC10081727.
Kim HG, Huot JR, Pin F, Belcher DJ, Bonetto A, Nader GA. Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner. J Appl Physiol (1985). 2022 Oct 6;. doi: 10.1152/japplphysiol.00247.2022. [Epub ahead of print] PubMed PMID: 36201323.select
Essex AL, Deosthale P, Huot JR, Davis HM, Momeni N, Bonetto A, Plotkin LI. miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice. Biol Sex Differ. 2022 Oct 1;13(1):56. doi: 10.1186/s13293-022-00465-9. PubMed PMID: 36183096; PubMed Central PMCID: PMC9526971.select
Huot JR, Pin F, Chatterjee R, Bonetto A. PGC1α overexpression preserves muscle mass and function in cisplatin-induced cachexia. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2480-2491. doi: 10.1002/jcsm.13035. Epub 2022 Jul 28. PubMed PMID: 35903870; PubMed Central PMCID: PMC9530502.select
Runco DV, Zimmers TA, Bonetto A. The urgent need to improve childhood cancer cachexia. Trends Cancer. 2022 Aug 3;. doi: 10.1016/j.trecan.2022.07.005. [Epub ahead of print] PubMed PMID: 35931609.select
Essex AL, Huot JR, Deosthale P, Wagner A, Figueras J, Davis A, Damrath J, Pin F, Wallace J, Bonetto A, Plotkin LI. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice. J Bone Miner Res. 2022 Jul;37(7):1366-1381. doi: 10.1002/jbmr.4572. Epub 2022 Jun 7. PubMed PMID: 35575023; PubMed Central PMCID: PMC9307075.select
Pin F, Huot JR, Bonetto A. The Mitochondria-Targeting Agent MitoQ Improves Muscle Atrophy, Weakness and Oxidative Metabolism in C26 Tumor-Bearing Mice. Front Cell Dev Biol. 2022;10:861622. doi: 10.3389/fcell.2022.861622. eCollection 2022. PubMed PMID: 35392166; PubMed Central PMCID: PMC8980422.
Huot JR, Pin F, Bonetto A. Erratum: Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity. Am J Cancer Res. 2022;12(3):1435. eCollection 2022. PubMed PMID: 35411220; PubMed Central PMCID: PMC8984878.select
Pin F, Jones AJ, Huot JR, Narasimhan A, Zimmers TA, Bonewald LF, Bonetto A. RANKL Blockade Reduces Cachexia and Bone Loss Induced by Non-Metastatic Ovarian Cancer in Mice. J Bone Miner Res. 2022 Mar;37(3):381-396. doi: 10.1002/jbmr.4480. Epub 2021 Dec 13. PubMed PMID: 34904285; PubMed Central PMCID: PMC8940654.select
Pin F, Prideaux M, Bonewald LF, Bonetto A. Osteocytes and Cancer. Curr Osteoporos Rep. 2021 Dec;19(6):616-625. doi: 10.1007/s11914-021-00712-9. Epub 2021 Nov 13. Review. PubMed PMID: 34773212; PubMed Central PMCID: PMC8963429.select
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF. Non-bone metastatic cancers promote osteocyte-induced bone destruction. Cancer Lett. 2021 Nov 1;520:80-90. doi: 10.1016/j.canlet.2021.06.030. Epub 2021 Jul 4. PubMed PMID: 34233150; PubMed Central PMCID: PMC8440379.select
Pin F, Bonewald LF, Bonetto A. Role of myokines and osteokines in cancer cachexia. Exp Biol Med (Maywood). 2021 Oct;246(19):2118-2127. doi: 10.1177/15353702211009213. Epub 2021 Apr 25. Review. PubMed PMID: 33899538; PubMed Central PMCID: PMC8524772.select
O'Connell TM, Golzarri-Arroyo L, Pin F, Barreto R, Dickinson SL, Couch ME, Bonetto A. Metabolic Biomarkers for the Early Detection of Cancer Cachexia. Front Cell Dev Biol. 2021;9:720096. doi: 10.3389/fcell.2021.720096. eCollection 2021. PubMed PMID: 34621740; PubMed Central PMCID: PMC8490779.select
Jones AJ, Campiti VJ, Alwani M, Novinger LJ, Bonetto A, Sim MW, Yesensky JA, Moore MG, Mantravadi AV. Skeletal Muscle Index's Impact on Discharge Disposition After Head and Neck Cancer Free Flap Reconstruction. Otolaryngol Head Neck Surg. 2021 Jul;165(1):59-68. doi: 10.1177/0194599820973232. Epub 2020 Dec 8. PubMed PMID: 33290190.select
Huot JR, Pin F, Bonetto A. Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity. Am J Cancer Res. 2021;11(6):2990-3001. eCollection 2021. PubMed PMID: 34249440; PubMed Central PMCID: PMC8263661.select
Rupert JE, Narasimhan A, Jengelley DHA, Jiang Y, Liu J, Au E, Silverman LM, Sandusky G, Bonetto A, Cao S, Lu X, O'Connell TM, Liu Y, Koniaris LG, Zimmers TA. Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia. J Exp Med. 2021 Jun 7;218(6). doi: 10.1084/jem.20190450. PubMed PMID: 33851955; PubMed Central PMCID: PMC8185651.select
Jones AJ, Campiti VJ, Alwani M, Novinger LJ, Tucker BJ, Bonetto A, Yesensky JA, Sim MW, Moore MG, Mantravadi AV. Sarcopenia is associated with blood transfusions in head and neck cancer free flap surgery. Laryngoscope Investig Otolaryngol. 2021 Apr;6(2):200-210. doi: 10.1002/lio2.530. eCollection 2021 Apr. PubMed PMID: 33869752; PubMed Central PMCID: PMC8035950.select
Hulmi JJ, Nissinen TA, Penna F, Bonetto A. Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments. Cells. 2021 Feb 28;10(3). doi: 10.3390/cells10030516. Review. PubMed PMID: 33671024; PubMed Central PMCID: PMC7997313.select
Ballarò R, Lopalco P, Audrito V, Beltrà M, Pin F, Angelini R, Costelli P, Corcelli A, Bonetto A, Szeto HH, O'Connell TM, Penna F. Targeting Mitochondria by SS-31 Ameliorates the Whole Body Energy Status in Cancer- and Chemotherapy-Induced Cachexia. Cancers (Basel). 2021 Feb 18;13(4). doi: 10.3390/cancers13040850. PubMed PMID: 33670497; PubMed Central PMCID: PMC7923037.select
Huot JR, Pin F, Essex AL, Bonetto A. MC38 Tumors Induce Musculoskeletal Defects in Colorectal Cancer. Int J Mol Sci. 2021 Feb 2;22(3). doi: 10.3390/ijms22031486. PubMed PMID: 33540821; PubMed Central PMCID: PMC7867345.select
Kim HG, Huot JR, Pin F, Guo B, Bonetto A, Nader GA. Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia. FASEB J. 2021 Feb;35(2):e21335. doi: 10.1096/fj.202002257R. PubMed PMID: 33527503; PubMed Central PMCID: PMC7863588.select
Huot JR, Pin F, Narasimhan A, Novinger LJ, Keith AS, Zimmers TA, Willis MS, Bonetto A. ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1779-1798. doi: 10.1002/jcsm.12642. Epub 2020 Nov 16. PubMed PMID: 33200567; PubMed Central PMCID: PMC7749603.select
Wang L, Halliday G, Huot JR, Satoh T, Baust JJ, Fisher A, Cook T, Hu J, Avolio T, Goncharov DA, Bai Y, Vanderpool RR, Considine RV, Bonetto A, Tan J, Bachman TN, Sebastiani A, McTiernan CF, Mora AL, Machado RF, Goncharova EA, Gladwin MT, Lai YC. Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):1543-1558. doi: 10.1161/ATVBAHA.119.313883. Epub 2020 Apr 9. PubMed PMID: 32268788; PubMed Central PMCID: PMC7255946.select
Alwani MM, Jones AJ, Novinger LJ, Pittelkow E, Bonetto A, Sim MW, Moore MG, Mantravadi AV. Impact of Sarcopenia on Outcomes of Autologous Head and Neck Free Tissue Reconstruction. J Reconstr Microsurg. 2020 Jun;36(5):369-378. doi: 10.1055/s-0040-1701696. Epub 2020 Feb 23. PubMed PMID: 32088918.select
Huot JR, Novinger LJ, Pin F, Narasimhan A, Zimmers TA, O'Connell TM, Bonetto A. Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia. JCI Insight. 2020 May 7;5(9). doi: 10.1172/jci.insight.136687. PubMed PMID: 32298240; PubMed Central PMCID: PMC7253026.select
Huot JR, Novinger LJ, Pin F, Bonetto A. HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia. Dis Model Mech. 2020 Jan 24;13(1). doi: 10.1242/dmm.043166. PubMed PMID: 31915140; PubMed Central PMCID: PMC6994937.select
Essex AL, Pin F, Huot JR, Bonewald LF, Plotkin LI, Bonetto A. Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice. Front Endocrinol (Lausanne). 2019;10:809. doi: 10.3389/fendo.2019.00809. eCollection 2019. PubMed PMID: 31803146; PubMed Central PMCID: PMC6877551.select
Mitra S, Tiwari K, Podicheti R, Pandhiri T, Rusch DB, Bonetto A, Zhang C, Mitra AK. Transcriptome Profiling Reveals Matrisome Alteration as a Key Feature of Ovarian Cancer Progression. Cancers (Basel). 2019 Oct 9;11(10). doi: 10.3390/cancers11101513. PubMed PMID: 31600962; PubMed Central PMCID: PMC6826756.select
O'Connell TM, Pin F, Couch ME, Bonetto A. Treatment with Soluble Activin Receptor Type IIB Alters Metabolic Response in Chemotherapy-Induced Cachexia. Cancers (Basel). 2019 Aug 21;11(9). doi: 10.3390/cancers11091222. PubMed PMID: 31438622; PubMed Central PMCID: PMC6770556.select
Pin F, Bonetto A, Bonewald LF, Klein GL. Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients. Front Endocrinol (Lausanne). 2019;10:543. doi: 10.3389/fendo.2019.00543. eCollection 2019. PubMed PMID: 31447786; PubMed Central PMCID: PMC6692456.select
Davis HM, Essex AL, Valdez S, Deosthale PJ, Aref MW, Allen MR, Bonetto A, Plotkin LI. Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice. Bone. 2019 Jul;124:89-102. doi: 10.1016/j.bone.2019.04.012. Epub 2019 Apr 24. PubMed PMID: 31028960; PubMed Central PMCID: PMC6543548.select
Pin F, Novinger LJ, Huot JR, Harris RA, Couch ME, O'Connell TM, Bonetto A. PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia. FASEB J. 2019 Jun;33(6):7778-7790. doi: 10.1096/fj.201802799R. Epub 2019 Mar 20. PubMed PMID: 30894018; PubMed Central PMCID: PMC6529344.select
Huot JR, Essex AL, Gutierrez M, Barreto R, Wang M, Waning DL, Plotkin LI, Bonetto A. Chronic Treatment with Multi-Kinase Inhibitors Causes Differential Toxicities on Skeletal and Cardiac Muscles. Cancers (Basel). 2019 Apr 23;11(4). doi: 10.3390/cancers11040571. PubMed PMID: 31018508; PubMed Central PMCID: PMC6520777.select
Pin F, Barreto R, Couch ME, Bonetto A, O'Connell TM. Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):140-154. doi: 10.1002/jcsm.12360. Epub 2019 Jan 24. PubMed PMID: 30680954; PubMed Central PMCID: PMC6438345.select
Pin F, Couch ME, Bonetto A. Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition. Curr Opin Support Palliat Care. 2018 Dec;12(4):420-426. doi: 10.1097/SPC.0000000000000382. Review. PubMed PMID: 30124526; PubMed Central PMCID: PMC6221433.select
Pin F, Barreto R, Kitase Y, Mitra S, Erne CE, Novinger LJ, Zimmers TA, Couch ME, Bonewald LF, Bonetto A. Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia. J Cachexia Sarcopenia Muscle. 2018 Aug;9(4):685-700. doi: 10.1002/jcsm.12311. Epub 2018 Jul 15. PubMed PMID: 30009406; PubMed Central PMCID: PMC6104117.select
Barreto R, Kitase Y, Matsumoto T, Pin F, Colston KC, Couch KE, O'Connell TM, Couch ME, Bonewald LF, Bonetto A. ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass. Sci Rep. 2017 Oct 31;7(1):14470. doi: 10.1038/s41598-017-15040-1. PubMed PMID: 29089584; PubMed Central PMCID: PMC5665981.select
Mota R, Rodríguez JE, Bonetto A, O'Connell TM, Asher SA, Parry TL, Lockyer P, McCudden CR, Couch ME, Willis MS. Post-translationally modified muscle-specific ubiquitin ligases as circulating biomarkers in experimental cancer cachexia. Am J Cancer Res. 2017;7(9):1948-1958. eCollection 2017. PubMed PMID: 28979816; PubMed Central PMCID: PMC5622228.select
Bonetto A, Kays JK, Parker VA, Matthews RR, Barreto R, Puppa MJ, Kang KS, Carson JA, Guise TA, Mohammad KS, Robling AG, Couch ME, Koniaris LG, Zimmers TA. Differential Bone Loss in Mouse Models of Colon Cancer Cachexia. Front Physiol. 2016;7:679. doi: 10.3389/fphys.2016.00679. eCollection 2016. PubMed PMID: 28123369; PubMed Central PMCID: PMC5225588.select
Bonetto A, Rupert JE, Barreto R, Zimmers TA. The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia. J Vis Exp. 2016 Nov 30;(117). doi: 10.3791/54893. PubMed PMID: 27929469; PubMed Central PMCID: PMC5226332.select
Barreto R, Mandili G, Witzmann FA, Novelli F, Zimmers TA, Bonetto A. Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways. Front Physiol. 2016;7:472. doi: 10.3389/fphys.2016.00472. eCollection 2016. PubMed PMID: 27807421; PubMed Central PMCID: PMC5070123.select
Barreto R, Waning DL, Gao H, Liu Y, Zimmers TA, Bonetto A. Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. Oncotarget. 2016 Jul 12;7(28):43442-43460. doi: 10.18632/oncotarget.9779. PubMed PMID: 27259276; PubMed Central PMCID: PMC5190036.select
Penna F, Bonetto A, Aversa Z, Minero VG, Rossi Fanelli F, Costelli P, Muscaritoli M. Effect of the specific proteasome inhibitor bortezomib on cancer-related muscle wasting. J Cachexia Sarcopenia Muscle. 2016 Jun;7(3):345-54. doi: 10.1002/jcsm.12050. Epub 2015 Jul 7. PubMed PMID: 27239411; PubMed Central PMCID: PMC4864285.select
Zimmers TA, Fishel ML, Bonetto A. STAT3 in the systemic inflammation of cancer cachexia. Semin Cell Dev Biol. 2016 Jun;54:28-41. doi: 10.1016/j.semcdb.2016.02.009. Epub 2016 Feb 6. Review. PubMed PMID: 26860754; PubMed Central PMCID: PMC4867234.select
Bonetto A, Andersson DC, Waning DL. Assessment of muscle mass and strength in mice. Bonekey Rep. 2015;4:732. doi: 10.1038/bonekey.2015.101. eCollection 2015. PubMed PMID: 26331011; PubMed Central PMCID: PMC4549925.select
Bonetto A, Penna F, Aversa Z, Mercantini P, Baccino FM, Costelli P, Ziparo V, Lucia S, Rossi Fanelli F, Muscaritoli M. Early changes of muscle insulin-like growth factor-1 and myostatin gene expression in gastric cancer patients. Muscle Nerve. 2013 Sep;48(3):387-92. doi: 10.1002/mus.23798. Epub 2013 Jul 17. PubMed PMID: 23861230.select
Merli M, Giusto M, Molfino A, Bonetto A, Rossi M, Ginanni Corradini S, Baccino FM, Rossi Fanelli F, Costelli P, Muscaritoli M. MuRF-1 and p-GSK3β expression in muscle atrophy of cirrhosis. Liver Int. 2013 May;33(5):714-21. doi: 10.1111/liv.12128. Epub 2013 Feb 24. PubMed PMID: 23432902.select
Pedroso FE, Spalding PB, Cheung MC, Yang R, Gutierrez JC, Bonetto A, Zhan R, Chan HL, Namias N, Koniaris LG, Zimmers TA. Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia. J Cachexia Sarcopenia Muscle. 2012 Sep;3(3):199-211. doi: 10.1007/s13539-012-0062-x. Epub 2012 Mar 29. PubMed PMID: 22476919; PubMed Central PMCID: PMC3424191.select
Bonetto A, Aydogdu T, Jin X, Zhang Z, Zhan R, Puzis L, Koniaris LG, Zimmers TA. JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E410-21. doi: 10.1152/ajpendo.00039.2012. Epub 2012 Jun 5. PubMed PMID: 22669242; PubMed Central PMCID: PMC3423125.select
Aversa Z, Bonetto A, Penna F, Costelli P, Di Rienzo G, Lacitignola A, Baccino FM, Ziparo V, Mercantini P, Rossi Fanelli F, Muscaritoli M. Changes in myostatin signaling in non-weight-losing cancer patients. Ann Surg Oncol. 2012 Apr;19(4):1350-6. doi: 10.1245/s10434-011-1720-5. Epub 2011 Apr 26. PubMed PMID: 21519918.select
Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, Zimmers TA. STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PLoS One. 2011;6(7):e22538. doi: 10.1371/journal.pone.0022538. Epub 2011 Jul 20. PubMed PMID: 21799891; PubMed Central PMCID: PMC3140523.
Aversa Z, Bonetto A, Costelli P, Minero VG, Penna F, Baccino FM, Lucia S, Rossi Fanelli F, Muscaritoli M. β-hydroxy-β-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. Int J Oncol. 2011 Mar;38(3):713-20. doi: 10.3892/ijo.2010.885. Epub 2010 Dec 23. PubMed PMID: 21184031.select
Bonetto A, Penna F, Minero VG, Reffo P, Costamagna D, Bonelli G, Baccino FM, Costelli P. Glutamine prevents myostatin hyperexpression and protein hypercatabolism induced in C2C12 myotubes by tumor necrosis factor-α. Amino Acids. 2011 Feb;40(2):585-94. doi: 10.1007/s00726-010-0683-3. Epub 2010 Jul 10. PubMed PMID: 20623149.select
Gazzerro E, Bonetto A, Minetti C. Caveolinopathies: translational implications of caveolin-3 in skeletal and cardiac muscle disorders. Handb Clin Neurol. 2011;101:135-42. doi: 10.1016/B978-0-08-045031-5.00010-4. Review. PubMed PMID: 21496630.select
Penna F, Bonetto A, Muscaritoli M, Costamagna D, Minero VG, Bonelli G, Rossi Fanelli F, Baccino FM, Costelli P. Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?. Int J Cancer. 2010 Oct 1;127(7):1706-17. doi: 10.1002/ijc.25146. PubMed PMID: 20039316.select
Gazzerro E, Assereto S, Bonetto A, Sotgia F, Scarfì S, Pistorio A, Bonuccelli G, Cilli M, Bruno C, Zara F, Lisanti MP, Minetti C. Therapeutic potential of proteasome inhibition in Duchenne and Becker muscular dystrophies. Am J Pathol. 2010 Apr;176(4):1863-77. doi: 10.2353/ajpath.2010.090468. Epub 2010 Mar 19. PubMed PMID: 20304949; PubMed Central PMCID: PMC2843476.select
Bonetto A, Penna F, Muscaritoli M, Minero VG, Rossi Fanelli F, Baccino FM, Costelli P. Are antioxidants useful for treating skeletal muscle atrophy?. Free Radic Biol Med. 2009 Oct 1;47(7):906-16. doi: 10.1016/j.freeradbiomed.2009.07.002. Epub 2009 Jul 8. Review. PubMed PMID: 19591922.select
Bonetto A, Penna F, Minero VG, Reffo P, Bonelli G, Baccino FM, Costelli P. Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice. Curr Cancer Drug Targets. 2009 Aug;9(5):608-16. doi: 10.2174/156800909789057015. Epub 2009 Aug 1. PubMed PMID: 19508174.select
Rossi S, Stoppani E, Martinet W, Bonetto A, Costelli P, Giuliani R, Colombo F, Preti A, Marchesini S, Fanzani A. The cytosolic sialidase Neu2 is degraded by autophagy during myoblast atrophy. Biochim Biophys Acta. 2009 Aug;1790(8):817-28. doi: 10.1016/j.bbagen.2009.04.006. Epub 2009 Apr 14. PubMed PMID: 19371771.select
Costelli P, Muscaritoli M, Bonetto A, Penna F, Reffo P, Bossola M, Bonelli G, Doglietto GB, Baccino FM, Rossi Fanelli F. Muscle myostatin signalling is enhanced in experimental cancer cachexia. Eur J Clin Invest. 2008 Jul;38(7):531-8. doi: 10.1111/j.1365-2362.2008.01970.x. PubMed PMID: 18578694.select
Muscaritoli M, Costelli P, Aversa Z, Bonetto A, Baccino FM, Rossi Fanelli F. New strategies to overcome cancer cachexia: from molecular mechanisms to the 'Parallel Pathway'. Asia Pac J Clin Nutr. 2008;17 Suppl 1:387-90. Review. PubMed PMID: 18296386.select
Costelli P, Muscaritoli M, Bossola M, Penna F, Reffo P, Bonetto A, Busquets S, Bonelli G, Lopez-Soriano FJ, Doglietto GB, Argilés JM, Baccino FM, Rossi Fanelli F. IGF-1 is downregulated in experimental cancer cachexia. Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R674-83. doi: 10.1152/ajpregu.00104.2006. Epub 2006 Apr 13. PubMed PMID: 16614058.